Identifying the Most Effective Single Agent for Treating Follicular Non-Hodgkin's Lymphoma

Public project summary

Follicular lymphoma is the most common form of Non-Hodgkin's lymphoma, a disease that takes the lives of thousands each year. It is often treated with a combination of drugs tailored to be the most suitable for each individual patient, but there are dozens of single agents and treatment regimens that makes it confusing for the patient. This project attempts to resolve some confusion by focusing on single agents that are the most effective in killing lymphocytic cells. In order to do this, a lab was set up to test the effects of three front-line single agents: cyclophosphamide, bendamustine, and fludarabine, on lymphocytic cell lines to see which single agent killed the largest amount of cells.